ChloroquineV1, Main, Exploration, bibRecord, 000F54

Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases

Identifieur interne : 000F54 ( Main/Exploration ); précédent : 000F53; suivant : 000F55

Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases

Auteurs : Sarah Braun [Allemagne] ; Marion Ferner [Allemagne] ; Kai Kronfeld [Allemagne] ; Matthias Griese [Allemagne]

Source :

Pediatric Pulmonology [ 8755-6863 ] ; 2015-04.

RBID : ISTEX:F34AA8E58D1C0E23BBC7ED4F1B0CE8BFCC153EE3

Descripteurs français

KwdFr :
- Antipaludiques (usage thérapeutique), Enfant, Humains, Hydroxychloroquine (usage thérapeutique), Pneumopathies interstitielles (traitement médicamenteux), Utilisation hors indication.
MESH :
- traitement médicamenteux : Pneumopathies interstitielles.
- usage thérapeutique : Antipaludiques, Hydroxychloroquine.
- Enfant, Humains, Utilisation hors indication.

English descriptors

KwdEn :
- Antimalarials (therapeutic use), Child, Humans, Hydroxychloroquine (therapeutic use), Lung Diseases, Interstitial (drug therapy), Off-Label Use.
MESH :
- chemical , therapeutic use : Antimalarials, Hydroxychloroquine.
- drug therapy : Lung Diseases, Interstitial.
- Child, Humans, Off-Label Use.

Abstract

Hydroxychloroquine (HCQ) is one of the drugs frequently used for the treatment of interstitial lung disease (ILD) in children (chILD). This use is off‐label and studies to analyze the effect and safety of HCQ in chILD are lacking. Therefore, a literature research on the usage of chloroquine (CQ) and HCQ in these conditions was done. Eighty‐five case reports and small series in the period from 1984 to 2013 were identified in which children with different diagnoses of ILD were treated with CQ or HCQ, sometimes in combination with other medication including steroids. A favorable response to HCQ or CQ was reported in 35 cases, whereas in the other cases the effect was negative or not clear. The dose of HCQ used was between 5 and 10 mg/kg body weight/day (bw/d). No pharmacokinetic studies have been done. The side effect profile in children seemed to be similar to that in adults. Most often gastrointestinal symptoms were reported. Three patients were found developing retinal changes during the treatment with CQ, whereas in none of the patients treated with HCQ retinal changes were reported. Based on retrospective case reports and small series likely to be reported with bias, the use of HCQ in chILD might be classified as safe. As no prospective data on efficacy and safety of HCQ in chILD are available, systematic collection is necessary. This may be achieved by web‐based registers like the European Management Platform for Childhood Interstitial Lung Diseases. Prospective and controlled investigations of HCQ in patients with chILD are mandatory. Pediatr Pulmonol. 2015; 50:410–419. © 2014 Wiley Periodicals, Inc.

Url:

https://api.istex.fr/ark:/67375/WNG-DFB7GSN5-V/fulltext.pdf

DOI: 10.1002/ppul.23133

Affiliations:

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<front><div type="abstract" xml:lang="en">Hydroxychloroquine (HCQ) is one of the drugs frequently used for the treatment of interstitial lung disease (ILD) in children (chILD). This use is off‐label and studies to analyze the effect and safety of HCQ in chILD are lacking. Therefore, a literature research on the usage of chloroquine (CQ) and HCQ in these conditions was done. Eighty‐five case reports and small series in the period from 1984 to 2013 were identified in which children with different diagnoses of ILD were treated with CQ or HCQ, sometimes in combination with other medication including steroids. A favorable response to HCQ or CQ was reported in 35 cases, whereas in the other cases the effect was negative or not clear. The dose of HCQ used was between 5 and 10 mg/kg body weight/day (bw/d). No pharmacokinetic studies have been done. The side effect profile in children seemed to be similar to that in adults. Most often gastrointestinal symptoms were reported. Three patients were found developing retinal changes during the treatment with CQ, whereas in none of the patients treated with HCQ retinal changes were reported. Based on retrospective case reports and small series likely to be reported with bias, the use of HCQ in chILD might be classified as safe. As no prospective data on efficacy and safety of HCQ in chILD are available, systematic collection is necessary. This may be achieved by web‐based registers like the European Management Platform for Childhood Interstitial Lung Diseases. Prospective and controlled investigations of HCQ in patients with chILD are mandatory. Pediatr Pulmonol. 2015; 50:410–419. © 2014 Wiley Periodicals, Inc.</div>
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Serveur d'exploration Chloroquine

Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases

Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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	Serveur d'exploration Chloroquine
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